SCHEMBL9523472

SCHEMBL9523472

O=[N+]([O-])c1ccc(C(c2ccccc2)n2ccnc2)cc1Cl

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 11/20 0.60
CYP17A1 P05093 2/20 0.54
CYP3A4 P08684 2/20 0.54
MEN1 O00255 1/20 0.54
NR1I2 O75469 1/20 0.54
USP2 O75604 1/20 0.54
ABCB11 O95342 1/20 0.54
ALDH1A1 P00352 1/20 0.54
PLA2G1B P04054 1/20 0.54
TP53 P04637 1/20 0.54
PGR P06401 1/20 0.54
HSP90AA1 P07900 1/20 0.54
MAPT P10636 1/20 0.54
IDO1 P14902 1/20 0.54
HPGD P15428 1/20 0.54
MAOA P21397 1/20 0.54
CNR1 P21554 1/20 0.54
HTR2A P28223 1/20 0.54
MAPK1 P28482 1/20 0.54
ADRA1A P35348 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14092698 0.92 CYP19A1 (0.63) CYP19A1CYP17A1CYP3A4CNR1MAPK1
SCHEMBL9523782 0.91 CYP19A1 (0.60) CYP19A1CYP17A1CYP3A4MEN1NR1I2
Oxalic Acid SCHEMBL9869246 0.89 CYP19A1 (0.56) CYP19A1CYP17A1CYP3A4MEN1NR1I2
Oxalic Acid SCHEMBL9526975 0.89 CYP19A1 (0.56) CYP19A1CYP17A1CYP3A4MEN1NR1I2
SCHEMBL11361986 0.85 CYP17A1 (0.62) CYP19A1CYP17A1CYP3A4MEN1NR1I2
SCHEMBL9191682 0.83 CYP19A1 (0.62) CYP19A1CYP17A1CYP3A4MEN1NR1I2
SCHEMBL6868753 0.81 CYP19A1 (0.89) CYP19A1CYP17A1CYP3A4MEN1NR1I2
SCHEMBL10581964 0.81 CYP19A1 (0.55) CYP19A1CYP17A1CYP3A4MEN1NR1I2
SCHEMBL9196108 0.81 CYP19A1 (0.55) CYP19A1CYP17A1CYP3A4MEN1NR1I2
Oxalic Acid SCHEMBL9526973 0.78 CYP19A1 (0.58) CYP19A1CYP17A1CYP3A4MEN1NR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1022184-C Process for preparing (1 H-imidzol-1-ylmethyl) substituted benzotriazole derivatives JANSSEN PHARMACEUTICA NV (BE) 1993-09-22 CN disclosed
EP-0293978-B1 (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1993-09-15 EP disclosed
US-5039677-A Estrogen inhibitor JANSSEN PHARMACEUTICA N.V. (CA) 1991-08-13 US disclosed
US-4943574-A AROMATASE INHIBITORS, ESTROGEN DISORDERS JANSSEN PHARMACEUTICA N.V. (BE) 1990-07-24 US disclosed
CN-88103408-A Process for preparing (1H-oxazol-1-ylmethyl) substituted benzotriazole derivatives 1988-12-14 CN disclosed
EP-0293978-A2 (1H-azol-1-ylmethyl)substituted benzotriazole derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1988-12-07 EP disclosed