Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.53 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.42 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884122 | 0.92 | CYP19A1 (0.62) | CYP19A1FNTAFNTBCNR1CYP3A4 | |
| Nitric Acid SCHEMBL9868688 | 0.85 | CYP19A1 (0.54) | CYP19A1FNTAFNTBCNR1CYP3A4 | |
| Nitric Acid SCHEMBL9524541 | 0.83 | CYP19A1 (0.48) | CYP19A1FNTAFNTBCNR1CYP3A4 | |
| Nitric Acid SCHEMBL9524380 | 0.82 | CYP19A1 (0.49) | CYP19A1FNTAFNTBCNR1CYP3A4 | |
| SCHEMBL14092717 | 0.77 | CYP19A1 (0.59) | CYP19A1FNTAFNTBCNR1CYP3A4 | |
| SCHEMBL14092716 | 0.77 | CYP19A1 (0.62) | CYP19A1FNTAFNTBCNR1CYP3A4 | |
| SCHEMBL3873790 | 0.76 | CYP19A1 (0.59) | CYP19A1FNTAFNTBCNR1CYP3A4 | |
| Nitric Acid SCHEMBL9527180 | 0.76 | CYP19A1 (0.53) | CYP19A1CNR1CYP3A4CYP26A1CYP17A1 | |
| SCHEMBL9523312 | 0.76 | CYP19A1 (0.65) | CYP19A1FNTAFNTBCYP3A4CYP2D6 | |
| SCHEMBL3279238 | 0.75 | CYP19A1 (0.60) | CYP19A1CNR1CYP3A4CYP2D6CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0293978-A2 | (1H-azol-1-ylmethyl)substituted benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-07 | — | — | EP | disclosed |