Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 3/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11381051 | 0.98 | CYP2C19 (0.38) | CYP2C19HDAC1MMELTA4HCETP | |
| SCHEMBL1768108 | 0.92 | HDAC1 (0.38) | CYP2C19HDAC1MMELTA4H | |
| SCHEMBL12308654 | 0.87 | HDAC1 (0.40) | HDAC1 | |
| SCHEMBL14795213 | 0.82 | MME (0.36) | CYP2C19HDAC1MMELTA4H | |
| SCHEMBL5512489 | 0.79 | CYP2C19 (0.54) | CYP2C19MMELTA4HCETPALDH1A1 | |
| SCHEMBL14417093 | 0.79 | CYP2C19 (0.39) | CYP2C19MMELTA4HCETPALDH1A1 | |
| SCHEMBL781736 | 0.78 | CETP (0.48) | CYP2C19MMECETPALDH1A1SMN1; SMN2 | |
| SCHEMBL5670213 | 0.78 | CETP (0.40) | CYP2C19MMELTA4HCETP | |
| SCHEMBL4732062 | 0.78 | KDM4E (0.44) | HDAC1CYP1A2 | |
| SCHEMBL19111018 | 0.78 | HDAC1 (0.35) | HDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330242-B1 | PYRIDAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1993-09-22 | — | — | EP | disclosed |
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4914093-A | CARDIOVASCULAR DISORDERS | SANKYO COMPANY LIMITED (JP) | 1990-04-03 | — | — | US | disclosed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0330242-A1 | Pyridazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1989-08-30 | — | — | EP | disclosed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | disclosed |
| EP-0178189-A2 | Pyridazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-04-16 | — | — | EP | disclosed |