Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542859 | 0.88 | MEN1 (0.60) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL4141608 | 0.88 | MEN1 (0.63) | MEN1KMT2ANPSR1PDK1SMN1; SMN2 | |
| SCHEMBL29239224 | 0.86 | MEN1 (0.57) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL1119073 | 0.83 | MEN1 (0.50) | MEN1KMT2ANPSR1PDK1SMN1; SMN2 | |
| SCHEMBL924595 | 0.83 | MEN1 (0.48) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL4293531 | 0.83 | MEN1 (0.54) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL28731650 | 0.83 | MEN1 (0.63) | MEN1KMT2ANPSR1PDK1SMN1; SMN2 | |
| SCHEMBL13059800 | 0.81 | MEN1 (0.60) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL28366638 | 0.80 | MEN1 (0.63) | MEN1KMT2ANPSR1PDK1SMN1; SMN2 | |
| SCHEMBL24571627 | 0.80 | MEN1 (0.56) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226267-B1 | OXA-, THIA- AND DIAZABICYCLOALKANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | BEECHAM GROUP PLC (GB) | 1993-01-13 | — | — | EP | disclosed |
| US-4883874-A | Azabicyclic intermediates | BEECHAM GROUP PLC. OF BEECHAM HOUSE (GB) | 1989-11-28 | — | — | US | disclosed |
| US-4826839-A | GASTROINTESTINAL DISORDERS, HEADACHES | BEECHAM GROUP P.L.C. (GB) | 1989-05-02 | — | — | US | disclosed |
| EP-0226267-A1 | Oxa-, thia- and diazabicycloalkane derivatives, process for their preparation and their use as pharmaceuticals | BEECHAM GROUP PLC (GB) | 1987-06-24 | — | — | EP | disclosed |