Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873254 | 0.87 | TSHR (0.58) | KDM4ETSHRCYP3A4HSD17B10LMNA | |
| SCHEMBL28060602 | 0.84 | KDM4E (0.49) | KDM4ETSHRCYP3A4HSD17B10MAPT | |
| SCHEMBL10498214 | 0.81 | TSHR (0.56) | KDM4ETSHRCYP3A4HSD17B10MAPT | |
| SCHEMBL2281556 | 0.77 | KDM4E (0.75) | KDM4ETSHRCYP3A4MAPTLMNA | |
| SCHEMBL21243801 | 0.76 | MAOB (0.58) | MAPTL3MBTL1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10497899 | 0.76 | CYP3A4 (0.68) | KDM4ETSHRCYP3A4MAPTLMNA | |
| SCHEMBL10111303 | 0.75 | CREBBP (0.53) | KDM4ETSHRCYP3A4HSD17B10LMNA | |
| SCHEMBL3988817 | 0.75 | KDM4E (0.57) | KDM4ETSHRCYP3A4HSD17B10MAPT | |
| SCHEMBL2479864 | 0.75 | TSHR (0.51) | KDM4ETSHRCYP3A4HSD17B10MAPT | |
| SCHEMBL7833873 | 0.74 | CYP3A4 (0.51) | KDM4ECYP3A4MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550576-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |