Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10746244 | 1.00 | ACE (0.47) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL10746240 | 1.00 | ACE (0.47) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9526142 | 1.00 | ACE (0.47) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL10747879 | 1.00 | ACE (0.47) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9526135 | 1.00 | ACE (0.47) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL10745898 | 0.90 | ACE (0.49) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9529993 | 0.90 | ACE (0.49) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9529991 | 0.90 | ACE (0.49) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL10746992 | 0.90 | ACE (0.49) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL10745889 | 0.90 | ACE (0.49) | ACEABCB11AGTR2PDE3ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365045-B1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1993-12-01 | — | — | EP | disclosed |
| US-4699905-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0161801-A2 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1985-11-21 | — | — | EP | disclosed |