Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.67 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CBLB | Q13191 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943988 | 0.91 | MAP3K5 (0.69) | MAP3K5CBLBKDRKCNK3KCNK9 | |
| SCHEMBL945572 | 0.88 | MAP3K5 (0.68) | MAP3K5CBLBLMNAGAASMN1; SMN2 | |
| SCHEMBL1082758 | 0.86 | MAP3K5 (0.68) | MAP3K5CBLBLMNAGAASMN1; SMN2 | |
| SCHEMBL943454 | 0.86 | MAP3K5 (0.63) | MAP3K5CBLBLMNAGAASMN1; SMN2 | |
| SCHEMBL14482051 | 0.86 | MAP3K5 (0.63) | MAP3K5CBLBLMNAGAASMN1; SMN2 | |
| SCHEMBL947893 | 0.85 | MAP3K5 (0.65) | MAP3K5CBLBLMNAGAASMN1; SMN2 | |
| SCHEMBL945824 | 0.85 | MAP3K5 (0.65) | MAP3K5CBLBLMNAGAA | |
| SCHEMBL946216 | 0.85 | MAP3K5 (0.65) | MAP3K5CBLBKDRLMNAGAA | |
| SCHEMBL947146 | 0.85 | MAP3K5 (0.62) | MAP3K5CBLBKDRLMNAGAA | |
| SCHEMBL1082642 | 0.85 | MAP3K5 (0.60) | MAP3K5CBLBKDRKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | claimed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | claimed |