Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | KYAT1 | Q16773 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526395 | 1.00 | APOBEC3A (0.36) | APOBEC3AAPOBEC3GFAAHKYAT1MAPT | |
| SCHEMBL3836644 | 0.86 | APOBEC3A (0.37) | APOBEC3AAPOBEC3GFAAHKYAT1MAPT | |
| SCHEMBL3836647 | 0.86 | APOBEC3A (0.37) | APOBEC3AAPOBEC3GFAAHKYAT1MAPT | |
| SCHEMBL950646 | 0.76 | MAPT (0.43) | APOBEC3AAPOBEC3GKYAT1MAPTALDH1A1 | |
| SCHEMBL950647 | 0.76 | MAPT (0.43) | APOBEC3AAPOBEC3GKYAT1MAPTALDH1A1 | |
| SCHEMBL14487036 | 0.76 | MAPT (0.43) | APOBEC3AAPOBEC3GKYAT1MAPTALDH1A1 | |
| SCHEMBL29134126 | 0.75 | MAPT (0.38) | APOBEC3AAPOBEC3GKYAT1MAPTALDH1A1 | |
| SCHEMBL20778292 | 0.75 | MAPT (0.38) | APOBEC3AAPOBEC3GKYAT1MAPTALDH1A1 | |
| SCHEMBL15100755 | 0.75 | MAPT (0.38) | APOBEC3AAPOBEC3GKYAT1MAPTALDH1A1 | |
| SCHEMBL212925 | 0.73 | CES1 (0.35) | MAPTALDH1A1CES2CES1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262412-A | Angiotensin II antagonists, hypotensive agents, treatment of congestive heart failure and glaucoma | MERCK & CO., INC. (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0523141-A4 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | — | 1993-04-21 | — | — | EP | disclosed |
| EP-0523141-A1 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | MERCK & CO. INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| WO-1991015479-A1 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | MERCK & CO., INC. (US) | 1991-10-17 | — | — | WO | disclosed |