Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1786936 | 0.80 | HDAC9 (0.44) | BRD4HDAC9POLBL3MBTL1NOTUM | |
| SCHEMBL8114506 | 0.80 | NOTUM (0.43) | BRD4HDAC9POLBL3MBTL1NOTUM | |
| SCHEMBL2055554 | 0.78 | BRD4 (0.41) | BRD4HDAC9POLBL3MBTL1NOTUM | |
| Hydrochloric Acid SCHEMBL9526798 | 0.78 | HDAC9 (0.43) | BRD4HDAC9POLBL3MBTL1NOTUM | |
| SCHEMBL1470334 | 0.75 | MEN1 (0.47) | BRD4HDAC9POLBL3MBTL1NOTUM | |
| SCHEMBL855461 | 0.74 | BRD4 (0.41) | BRD4HDAC9POLBL3MBTL1NOTUM | |
| SCHEMBL856896 | 0.74 | MME (0.41) | BRD4HDAC9NOTUMALDH1A1MME | |
| SCHEMBL31034935 | 0.74 | MME (0.41) | BRD4HDAC9NOTUMALDH1A1MME | |
| Hydrochloric Acid SCHEMBL11790216 | 0.72 | HDAC9 (0.38) | HDAC9NOTUMALDH1A1KDM4EHPGD | |
| SCHEMBL2055543 | 0.72 | IDH1 (0.44) | HDAC9POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310745-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | ORION-YHTYMÄ OY (FI) | 1993-01-27 | — | — | EP | disclosed |
| EP-0183492-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos-Yhtyma Oy (FI) | 1989-11-15 | — | — | EP | disclosed |
| US-4689339-A | 4-dihydroinden-2-yl-, 4-tetrahydronaphth-2-yl-, and 4-dihydrobenzofuran-2-ylimidazoles, useful to block α2 -adrenergic receptors | FARMOS YHTYMA OY (FI) | 1987-08-25 | — | — | US | disclosed |
| EP-0183492-A1 | Substituted imidazole derivatives and their preparation and use | Farmos-Yhtyma Oy (FI) | 1986-06-04 | — | — | EP | disclosed |