Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 8/20 | 0.59 |
| ▸ | ATIC | P31939 | 3/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.43 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.43 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.43 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524456 | 0.94 | GART (0.59) | GARTATICDHFRFOLR2FOLR1 | |
| SCHEMBL9523918 | 0.90 | GART (0.59) | GARTATICDHFRSOST | |
| SCHEMBL9524099 | 0.88 | GART (0.58) | GARTATICDHFRSOST | |
| Lometrexol SCHEMBL9045915 | 0.88 | GART (0.75) | GARTATICDHFR | |
| Lometrexol SCHEMBL12022771 | 0.88 | GART (0.75) | GARTATICDHFR | |
| SCHEMBL9523254 | 0.87 | GART (0.62) | GARTATICDHFR | |
| SCHEMBL7487513 | 0.87 | GART (0.71) | GARTATICDHFR | |
| SCHEMBL9523528 | 0.86 | GART (0.59) | GARTATICDHFRFOLR2FOLR1 | |
| SCHEMBL7488545 | 0.85 | GART (0.71) | GARTATICDHFR | |
| SCHEMBL8819556 | 0.85 | GART (0.60) | GARTATICDHFRFOLR2FOLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327190-B1 | Pyrido(2,3-d)pyrimidine derivatives | UNIV PRINCETON (US) | 1993-12-08 | — | — | EP | disclosed |
| US-4889859-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0327190-A1 | Pyrido(2,3-d)pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-08-09 | — | — | EP | disclosed |