Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526563 | 0.91 | ACE (0.41) | ACE | |
| SCHEMBL9527568 | 0.88 | ACE (0.45) | ACE | |
| SCHEMBL9526900 | 0.88 | ACE (0.59) | ACE | |
| SCHEMBL9527222 | 0.85 | ACE (0.51) | ACE | |
| SCHEMBL9526430 | 0.85 | ACE (0.51) | ACE | |
| SCHEMBL9526291 | 0.84 | ACE (0.46) | ACE | |
| SCHEMBL9527641 | 0.82 | ACE (0.51) | ACE | |
| SCHEMBL9527070 | 0.82 | ACE (0.48) | ACE | |
| SCHEMBL10376319 | 0.81 | ACE (0.48) | ACE | |
| SCHEMBL9530659 | 0.81 | ACE (0.48) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365045-B1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1993-12-01 | — | — | EP | disclosed |
| EP-0365045-A1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1990-04-25 | — | — | EP | disclosed |
| US-4699905-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0161801-A2 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1985-11-21 | — | — | EP | disclosed |