Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527580 | 1.00 | HTR2A (0.57) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL8432284 | 0.84 | HTR2A (0.66) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL21254625 | 0.84 | HTR2A (0.66) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL9367510 | 0.82 | HTR2A (0.55) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL9367505 | 0.82 | HTR2A (0.55) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL9367603 | 0.80 | HTR2A (0.58) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL9367599 | 0.80 | HTR2A (0.58) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL9371171 | 0.80 | HTR2A (0.74) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL9371168 | 0.80 | HTR2A (0.74) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL10629339 | 0.80 | HRH3 (0.43) | SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0286495-B1 | MORPHOLINE DERIVATIVES, THEIR PROCESS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1993-05-12 | — | — | EP | claimed |
| US-4782054-A | ANTIISCHEMIC, ANTIHYPOXIC, STIMULANTS | ADIR ET COMPAGNIE (FR) | 1988-11-01 | — | — | US | claimed |
| US-5026701-A | Antiischaemic agent, antidepressants, for treating cerebral aging | ADIR ET COMPAGNIE (FR) | 1991-06-25 | — | — | US | disclosed |
| US-4782054-A | ANTIISCHEMIC, ANTIHYPOXIC, STIMULANTS | ADIR ET COMPAGNIE (FR) | 1988-11-01 | — | — | US | disclosed |