Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.60 |
| ▸ | DRD4 | P21917 | 7/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528170 | 1.00 | HRH3 (0.60) | HRH3DRD4SRCERBB2EPHA2 | |
| SCHEMBL10629334 | 0.86 | HRH3 (0.43) | HRH3DRD4SRCEPHA2KDR | |
| SCHEMBL10629339 | 0.86 | HRH3 (0.43) | HRH3DRD4SRCEPHA2KDR | |
| SCHEMBL10634689 | 0.86 | DRD4 (0.44) | HRH3DRD4 | |
| SCHEMBL10634697 | 0.86 | DRD4 (0.44) | HRH3DRD4 | |
| SCHEMBL10630054 | 0.84 | DRD4 (0.46) | HRH3DRD4 | |
| SCHEMBL10630048 | 0.84 | DRD4 (0.46) | HRH3DRD4 | |
| SCHEMBL11630724 | 0.84 | HRH3 (0.66) | HRH3DRD4ERBB2EPHA2KDR | |
| SCHEMBL10630160 | 0.83 | DRD4 (0.47) | DRD4 | |
| SCHEMBL10630155 | 0.83 | DRD4 (0.47) | DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0286495-B1 | MORPHOLINE DERIVATIVES, THEIR PROCESS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1993-05-12 | — | — | EP | claimed |
| US-4782054-A | ANTIISCHEMIC, ANTIHYPOXIC, STIMULANTS | ADIR ET COMPAGNIE (FR) | 1988-11-01 | — | — | US | claimed |
| US-4782054-A | ANTIISCHEMIC, ANTIHYPOXIC, STIMULANTS | ADIR ET COMPAGNIE (FR) | 1988-11-01 | — | — | US | disclosed |