SCHEMBL9528573

CC(C)c1cc(-c2ccccc2)nc(-c2ccc(F)cc2)c1/C=C/[C@@H]1C[C@@H](O)CC(=O)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	HMGCR	P04035	12/20	1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9022338	1.00	HMGCR (1.00)	HMGCR
SCHEMBL10424088	0.93	HMGCR (0.87)	HMGCR
SCHEMBL9022250	0.93	HMGCR (0.86)	HMGCR
SCHEMBL9022313	0.93	HMGCR (0.86)	HMGCR
SCHEMBL10424677	0.92	HMGCR (0.85)	HMGCR
SCHEMBL9022891	0.91	HMGCR (0.84)	HMGCR
SCHEMBL10424009	0.91	HMGCR (0.83)	HMGCR
SCHEMBL9022876	0.90	HMGCR (0.81)	HMGCR
SCHEMBL10425481	0.89	HMGCR (0.79)	HMGCR
SCHEMBL10424071	0.88	HMGCR (0.78)	HMGCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0319847-B1	METHOD FOR THE PREPARATION OF OPTICALLY ACTIVE 3-DESMETHYLMEVALONIC ACID DERIVATIVES AND INTERMEDIATE COMPOUNDS	HOECHST AKTIENGESELLSCHAFT (DE)	1993-07-28	—	—	EP	disclosed
US-4977279-A	Anticholesterol agents	HOECHST AKTIENGESELLSCHAFT (DE)	1990-12-11	—	—	US	disclosed
US-4970313-A	Optically active 3-demethylmevalonic acid derivatives, and intermediates	HOECHST AKTIENGESELLSCHAFT (DE)	1990-11-13	—	—	US	disclosed
EP-0319847-A2	Method for the preparation of optically active 3-desmethylmevalonic acid derivatives and intermediate compounds	HOECHST AKTIENGESELLSCHAFT (DE)	1989-06-14	—	—	EP	disclosed