Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 15/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.59 |
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | MITF | O75030 | 6/20 | 0.59 |
| ▸ | RAB9A | P51151 | 12/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 11/20 | 0.51 |
| ▸ | LMNA | P02545 | 9/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9372672 | 0.85 | HTT (0.60) | HTTALDH1A1NPC1SMN1; SMN2MITF | |
| SCHEMBL9372329 | 0.82 | HTT (0.57) | HTTALDH1A1NPC1SMN1; SMN2MITF | |
| SCHEMBL4190041 | 0.79 | HTT (0.55) | HTTALDH1A1NPC1SMN1; SMN2MITF | |
| SCHEMBL9372983 | 0.78 | HTT (0.54) | HTTALDH1A1NPC1SMN1; SMN2MITF | |
| SCHEMBL980058 | 0.77 | HTT (0.60) | HTTALDH1A1NPC1SMN1; SMN2MITF | |
| SCHEMBL15674013 | 0.76 | HTT (0.59) | HTTALDH1A1NPC1SMN1; SMN2MITF | |
| SCHEMBL10884770 | 0.74 | HTT (0.53) | HTTALDH1A1NPC1SMN1; SMN2MITF | |
| SCHEMBL9234092 | 0.74 | HTT (0.57) | HTTALDH1A1NPC1SMN1; SMN2MITF | |
| SCHEMBL7806721 | 0.73 | HTT (0.46) | HTTALDH1A1NPC1SMN1; SMN2MITF | |
| SCHEMBL15674046 | 0.73 | HTT (0.58) | HTTALDH1A1NPC1SMN1; SMN2MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| EP-0201765-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-09-18 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |
| US-4892947-A | 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| EP-0201765-A2 | 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-11-20 | — | — | EP | disclosed |