Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.42 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10743630 | 1.00 | POLB (0.62) | POLBLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2222163 | 0.86 | POLB (0.63) | POLBMEN1KMT2ASMN1; SMN2HPGDS | |
| SCHEMBL2222173 | 0.86 | POLB (0.63) | POLBMEN1KMT2ASMN1; SMN2HPGDS | |
| SCHEMBL13777929 | 0.84 | POLB (0.64) | POLBMEN1KMT2ASMN1; SMN2HPGDS | |
| SCHEMBL10763278 | 0.81 | POLB (0.61) | POLBLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4999644 | 0.80 | POLB (0.70) | POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8236782 | 0.79 | POLB (0.53) | POLBMEN1KMT2ASMN1; SMN2HPGDS | |
| SCHEMBL11370753 | 0.79 | POLB (0.47) | POLBLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11254116 | 0.79 | POLB (0.47) | POLBLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7624989 | 0.79 | POLB (0.69) | POLBMEN1KMT2ASMN1; SMN2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210701-B1 | PEPTIDO-MIMETIC SUBSTANCES WITH HYPOTENSIVE ACTION | POLIFARMA S.p.A. (IT) | 1993-03-17 | — | — | EP | disclosed |
| US-4713368-A | Peptido-mimetic substances with hypotensive action | ENIRICERCHE S.P.A. (IT) | 1987-12-15 | — | — | US | disclosed |
| EP-0210701-A2 | Peptido-mimetic substances with hypotensive action | POLIFARMA S.p.A. (IT) | 1987-02-04 | — | — | EP | disclosed |