Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531492 | 1.00 | HCAR2 (0.47) | HCAR2ESR1ESR2CYP2D6KIF11 | |
| SCHEMBL8625307 | 0.87 | HCAR2 (0.59) | HCAR2ESR1ESR2CYP2D6KIF11 | |
| SCHEMBL27534210 | 0.87 | HCAR2 (0.59) | HCAR2ESR1ESR2CYP2D6KIF11 | |
| SCHEMBL8625297 | 0.87 | HCAR2 (0.59) | HCAR2ESR1ESR2CYP2D6KIF11 | |
| SCHEMBL10424372 | 0.83 | HCAR2 (0.45) | HCAR2ESR1ESR2CYP2D6KIF11 | |
| SCHEMBL27704799 | 0.83 | HCAR2 (0.49) | HCAR2ESR1ESR2CYP2D6KIF11 | |
| SCHEMBL27534212 | 0.81 | HCAR2 (0.69) | HCAR2ESR1ESR2CYP2D6CRHBP | |
| SCHEMBL28803484 | 0.81 | HCAR2 (0.69) | HCAR2ESR1ESR2CYP2D6CRHBP | |
| SCHEMBL10983709 | 0.81 | ESR1 (0.50) | HCAR2ESR1ESR2CYP2D6KIF11 | |
| SCHEMBL11156533 | 0.80 | HCAR2 (0.53) | HCAR2ESR1ESR2CYP2D6KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252744-B1 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | LILLY CO ELI (US) | 1993-12-15 | — | — | EP | disclosed |
| US-4734498-A | 3β-succinimidoazetidinones as chiral intermediates | ELI LILLY AND COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0252744-A2 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | ELI LILLY AND COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |