Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 4/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528670 | 0.86 | SLC6A4 (0.39) | SLC6A4PDE1APDE1BPDE1CCHRNA7 | |
| SCHEMBL10491404 | 0.81 | PDE1A (0.37) | SLC6A4PDE1APDE1BPDE1CCYP3A4 | |
| SCHEMBL10491371 | 0.76 | CYP3A4 (0.44) | SLC6A4PDE1APDE1BPDE1CCYP3A4 | |
| Vindeburnol SCHEMBL29781403 | 0.74 | PDE1A (0.36) | SLC6A4PDE1APDE1BPDE1CCHRNA7 | |
| Vindeburnol SCHEMBL2233670 | 0.74 | PDE1A (0.36) | SLC6A4PDE1APDE1BPDE1CCHRNA7 | |
| Vindeburnol SCHEMBL29789430 | 0.74 | PDE1A (0.36) | SLC6A4PDE1APDE1BPDE1CCHRNA7 | |
| Vindeburnol SCHEMBL15100271 | 0.74 | PDE1A (0.36) | SLC6A4PDE1APDE1BPDE1CCHRNA7 | |
| Vindeburnol SCHEMBL9501993 | 0.74 | PDE1A (0.36) | SLC6A4PDE1APDE1BPDE1CCHRNA7 | |
| Vindeburnol SCHEMBL9502133 | 0.74 | PDE1A (0.36) | SLC6A4PDE1APDE1BPDE1CCHRNA7 | |
| Vindeburnol SCHEMBL14194221 | 0.74 | PDE1A (0.36) | SLC6A4PDE1APDE1BPDE1CCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287468-B1 | 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-10 | — | — | EP | disclosed |
| US-4886802-A | ANALGESICS | ROUSSEL UCLAF (FR) | 1989-12-12 | — | — | US | disclosed |
| EP-0287468-A2 | 17-Aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-19 | — | — | EP | disclosed |