Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435402 | 0.76 | ESR2 (0.56) | MYCWDR5CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL20183521 | 0.76 | HSD17B10 (0.53) | MYCWDR5CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL6696407 | 0.73 | HSD17B10 (0.50) | MYCWDR5CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL10061705 | 0.72 | ESR2 (0.54) | MYCWDR5CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL6606339 | 0.70 | ESR2 (0.49) | MYCWDR5CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL360601 | 0.70 | ESR2 (0.59) | MYCWDR5CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29170999 | 0.70 | ESR2 (0.59) | MYCWDR5CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL20405268 | 0.70 | ESR2 (0.63) | CYP1A2CYP3A4HSD17B10ALDH1A1TSHR | |
| SCHEMBL6957086 | 0.69 | ESR2 (0.47) | MYCWDR5CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL6606543 | 0.69 | HRH4 (0.54) | MYCWDR5CYP1A2CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |