Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.52 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630002 | 0.90 | FEN1 (0.50) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9629723 | 0.82 | FEN1 (0.48) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9630056 | 0.81 | FEN1 (0.47) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL10377174 | 0.80 | FEN1 (0.41) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9352322 | 0.80 | FEN1 (0.47) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9629050 | 0.79 | HPGD (0.47) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9629850 | 0.79 | HPGD (0.47) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9629742 | 0.79 | CYP2C19 (0.47) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9535305 | 0.79 | FEN1 (0.55) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9532938 | 0.79 | FEN1 (0.55) | PDE4APDE4BPDE4CPDE4DFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241291-B1 | ARYL-SUBSTITUTED NAPHTHYRIDINE AND PYRIDOPYRAZINE DERIVATIVES | SCHERING CORPORATION (US) | 1993-06-02 | — | — | EP | claimed |
| EP-0241291-A2 | Aryl-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1987-10-14 | — | — | EP | claimed |
| EP-0241291-B1 | ARYL-SUBSTITUTED NAPHTHYRIDINE AND PYRIDOPYRAZINE DERIVATIVES | SCHERING CORPORATION (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5045542-A | Immune suppression method employing aryl-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1991-09-03 | — | — | US | disclosed |
| US-5011860-A | Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases | SCHERING CORPORATION (US) | 1991-04-30 | — | — | US | disclosed |
| US-4882332-A | Immune suppression method employing arly-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| US-4866061-A | TREATMENT OF ALLERGIC REACTIONS, ULCERS, INFLAMMATION | SCHERING CORPORATION (US) | 1989-09-12 | — | — | US | disclosed |
| US-4760073-A | Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents | SCHERING CORPORATION (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0241291-A2 | Aryl-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1987-10-14 | — | — | EP | disclosed |