Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 8/20 | 0.73 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24091985 | 0.84 | PRCP (1.00) | PRCPSLC22A1GAAGID4RECQL | |
| SCHEMBL31158625 | 0.84 | PRCP (1.00) | PRCPSLC22A1GAAGID4RECQL | |
| SCHEMBL1012767 | 0.84 | PRCP (1.00) | PRCPSLC22A1GAAGID4RECQL | |
| SCHEMBL29768316 | 0.84 | PRCP (1.00) | PRCPSLC22A1GAAGID4RECQL | |
| SCHEMBL31569038 | 0.80 | PRCP (0.77) | PRCPSLC22A1GAAGID4RECQL | |
| SCHEMBL28209057 | 0.76 | PRCP (0.71) | PRCPSLC22A1GAAGID4RECQL | |
| SCHEMBL4144168 | 0.76 | PRCP (0.71) | PRCPSLC22A1GAAGID4RECQL | |
| SCHEMBL16968353 | 0.76 | PRCP (0.71) | PRCPSLC22A1GAAGID4RECQL | |
| SCHEMBL24845654 | 0.76 | PRCP (0.71) | PRCPSLC22A1GAAGID4RECQL | |
| SCHEMBL9530395 | 0.74 | PRCP (0.67) | PRCPSLC22A1GAAGID4RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330360-B1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SMITHKLINE BEECHAM FARMA (IT) | 1993-12-01 | — | — | EP | disclosed |
| US-4954509-A | Isoquinoline derivatives and their use as analgesics | DR. LO. ZAMBELETTI S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0330360-A1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1989-08-30 | — | — | EP | disclosed |
| US-4806547-A | Isoquinoline derivatives, analgesic compounds thereof and method of treating pain | DR. LO. ZAMBELETTI SPA (IT) | 1989-02-21 | — | — | US | disclosed |