Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.54 |
| ▸ | ABCC9 | O60706 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529658 | 0.88 | SIRT2 (0.52) | SIRT2SIRT1ABCC9KDM4EABCB1 | |
| SCHEMBL9530742 | 0.86 | SIRT2 (0.51) | SIRT2SIRT1ABCC9KDM4EABCB1 | |
| SCHEMBL9354203 | 0.83 | SIRT2 (0.57) | SIRT2SIRT1ABCC9KDM4EABCB1 | |
| SCHEMBL9272118 | 0.83 | SIRT2 (0.72) | SIRT2SIRT1 | |
| SCHEMBL9267741 | 0.82 | SIRT2 (0.57) | SIRT2SIRT1ABCB1 | |
| SCHEMBL9265874 | 0.82 | SIRT2 (0.52) | SIRT2SIRT1ABCC9KDM4EABCB1 | |
| SCHEMBL9215032 | 0.82 | SIRT2 (0.52) | SIRT2SIRT1ABCC9KDM4EABCB1 | |
| SCHEMBL9180509 | 0.82 | SIRT2 (0.52) | SIRT2SIRT1ABCC9KDM4EABCB1 | |
| SCHEMBL9177750 | 0.82 | SIRT2 (0.52) | SIRT2SIRT1ABCC9KDM4EABCB1 | |
| SCHEMBL4257277 | 0.81 | CNR1 (0.54) | SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0138134-B1 | CHROMAN DERIVATIVES | BEECHAM GROUP PLC (GB) | 1989-04-19 | — | — | EP | claimed |
| EP-0536424-A1 | NOVEL BENZOPYRAN DERIVATIVE | Japan Tobacco Inc. (JP) | 1993-04-14 | — | — | EP | disclosed |
| EP-0138134-B1 | CHROMAN DERIVATIVES | BEECHAM GROUP PLC (GB) | 1989-04-19 | — | — | EP | disclosed |