Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13664666 | 0.73 | POLB (0.34) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL7848700 | 0.71 | GAA (0.46) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL12923292 | 0.70 | GAA (0.44) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL4577419 | 0.70 | GAA (0.44) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL10826905 | 0.70 | KMT2A (0.45) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL8264963 | 0.70 | CYP2C19 (0.50) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL28630400 | 0.70 | GAA (0.44) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL1299240 | 0.68 | KMT2A (0.44) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL8266120 | 0.68 | KMT2A (0.44) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL867537 | 0.68 | CYP2C19 (0.53) | KDM4EGAAMGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236931-B1 | Aromatic omega-alkylimino-tetrahydro-6H-1,3-Thiazin-6-one derivatives | MERRELL DOW PHARMA (US) | 1993-12-29 | — | — | EP | disclosed |
| US-4704389-A | ANXIOLYTIC, HYPOTENSIVE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0236931-A2 | Aromatic omega-alkylimino-tetrahydro-6H-1,3-Thiazin-6-one derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-09-16 | — | — | EP | disclosed |