Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.82 |
| ▸ | TOP2A | P11388 | 5/20 | 0.57 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.57 |
| ▸ | TOP1 | P11387 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | ALB | P02768 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TUBB | P07437 | 1/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12637996 | 0.93 | KDM4E (0.94) | KDM4ETOP2ATOP2BTOP1ALDH1A1 | |
| Marbofloxacin SCHEMBL134860 | 0.90 | KDM4E (1.00) | KDM4ETOP2ATOP2BTOP1ALDH1A1 | |
| Marbofloxacin SCHEMBL29355042 | 0.90 | KDM4E (1.00) | KDM4ETOP2ATOP2BTOP1ALDH1A1 | |
| SCHEMBL9533821 | 0.89 | KDM4E (0.83) | KDM4ETOP2ATOP2BTOP1ALDH1A1 | |
| Marbofloxacin SCHEMBL10563057 | 0.89 | KDM4E (0.98) | KDM4ETOP2ATOP2BTOP1ALDH1A1 | |
| SCHEMBL10565366 | 0.89 | KDM4E (0.73) | KDM4ETOP2ATOP2BTOP1ALDH1A1 | |
| SCHEMBL10564993 | 0.88 | KDM4E (0.82) | KDM4ETOP2ATOP2BTOP1ALDH1A1 | |
| SCHEMBL10574612 | 0.88 | KDM4E (0.72) | KDM4ETOP2ATOP2BTOP1ALDH1A1 | |
| SCHEMBL12665530 | 0.87 | KDM4E (0.84) | KDM4ETOP2ATOP2BTOP1ALDH1A1 | |
| SCHEMBL9534568 | 0.87 | KDM4E (0.80) | KDM4ETOP2ATOP2BTOP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259804-B1 | Pyrido[3,2,1-ij]-1,3,4-benzoxadiazine derivatives, process for their preparation, resulting pharmaceutical preparations and intermediates for use in the process | HOFFMANN LA ROCHE (CH) | 1993-11-18 | — | — | EP | claimed |
| EP-0259804-B1 | Pyrido[3,2,1-ij]-1,3,4-benzoxadiazine derivatives, process for their preparation, resulting pharmaceutical preparations and intermediates for use in the process | HOFFMANN LA ROCHE (CH) | 1993-11-18 | — | — | EP | disclosed |
| US-4864023-A | MICROBIOCIDES, BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4801584-A | ANTIMICROBIAL | HOFFMANN-LA ROCHE INC. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0259804-A2 | Pyrido[3,2,1-ij]-1,3,4-benzoxadiazine derivatives, process for their preparation, resulting pharmaceutical preparations and intermediates for use in the process | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-16 | — | — | EP | disclosed |