Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9431516 | 0.85 | CYP19A1 (0.56) | CYP19A1HTR1ASIGMAR1ACHEALDH1A1 | |
| SCHEMBL24228697 | 0.84 | CYP19A1 (0.57) | CYP19A1HTR1ASIGMAR1ACHEALDH1A1 | |
| SCHEMBL874650 | 0.83 | METAP1 (0.57) | CYP19A1HTR1ASIGMAR1ACHEMETAP1 | |
| SCHEMBL11026228 | 0.81 | CYP19A1 (0.49) | CYP19A1HTR1ASIGMAR1ACHEALDH1A1 | |
| SCHEMBL14061976 | 0.79 | CYP26A1 (0.64) | CYP19A1ALDH1A1SMN1; SMN2TP53CYP1A2 | |
| SCHEMBL17211818 | 0.79 | METAP1 (0.48) | CYP19A1METAP1CYP26A1 | |
| SCHEMBL5608451 | 0.78 | CYP19A1 (0.59) | CYP19A1HTR1ASIGMAR1ACHEALDH1A1 | |
| SCHEMBL11734950 | 0.78 | CYP19A1 (0.59) | CYP19A1HTR1ASIGMAR1ACHEALDH1A1 | |
| SCHEMBL6307397 | 0.78 | CYP19A1 (0.59) | CYP19A1HTR1ASIGMAR1ACHEALDH1A1 | |
| SCHEMBL7305594 | 0.78 | CYP19A1 (0.50) | CYP19A1HTR1ASIGMAR1ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525123-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES. | UPJOHN CO (US) | 1993-02-03 | — | — | EP | claimed |
| EP-0530198-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991015491-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |
| US-4910212-A | Containing 1,2,4-triazole or imidazole ring | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-03-20 | — | — | US | disclosed |
| EP-0281283-A1 | Heterocyclic compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-09-07 | — | — | EP | disclosed |