Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534335 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2FPR2TLR8ALDH1A1POLB | |
| SCHEMBL9536637 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2FPR2TLR8 | |
| SCHEMBL9536344 | 0.74 | SMN1; SMN2 (0.39) | SMN1; SMN2FPR2TLR8 | |
| SCHEMBL9485376 | 0.69 | S1PR1 (0.39) | S1PR2S1PR1S1PR3 | |
| SCHEMBL27700936 | 0.67 | TLR8 (0.53) | SMN1; SMN2TLR8ALDH1A1POLBKMT2A | |
| SCHEMBL9538934 | 0.67 | SMN1; SMN2 (0.46) | SMN1; SMN2FPR2TLR8ALDH1A1POLB | |
| SCHEMBL4436250 | 0.67 | SMN1; SMN2 (0.50) | SMN1; SMN2FPR2TLR8ALDH1A1POLB | |
| SCHEMBL10520884 | 0.66 | SMN1; SMN2 (0.47) | SMN1; SMN2FPR2TLR8ALDH1A1POLB | |
| SCHEMBL9533128 | 0.66 | SMN1; SMN2 (0.45) | SMN1; SMN2FPR2TLR8 | |
| SCHEMBL9534900 | 0.66 | SMN1; SMN2 (0.45) | SMN1; SMN2FPR2TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528957-A4 | FIVE-MEMBERED RING ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | — | 1993-05-05 | — | — | EP | disclosed |
| EP-0528957-A1 | FIVE-MEMBERED RING ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-03-03 | — | — | EP | disclosed |
| WO-1991016889-A1 | FIVE-MEMBERED RING ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-11-14 | — | — | WO | disclosed |