Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.54 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9534990 | 1.00 | HRH1 (0.60) | HRH1KCNH2SSTR5 | |
| SCHEMBL6998640 | 0.87 | SSTR5 (0.66) | HRH1KCNH2SSTR5 | |
| SCHEMBL7985310 | 0.86 | KDM4E (0.56) | HRH1KCNH2 | |
| Oxalic Acid SCHEMBL9539822 | 0.86 | HRH1 (0.47) | HRH1KCNH2 | |
| Oxalic Acid SCHEMBL9539814 | 0.86 | HRH1 (0.47) | HRH1KCNH2 | |
| Oxalic Acid SCHEMBL10384125 | 0.85 | KCNH2 (0.50) | HRH1KCNH2 | |
| SCHEMBL9536951 | 0.85 | KDM4E (0.53) | HRH1KCNH2 | |
| Oxalic Acid SCHEMBL10384126 | 0.85 | KCNH2 (0.50) | HRH1KCNH2 | |
| SCHEMBL9536500 | 0.83 | HRH1 (0.62) | HRH1KCNH2SSTR5 | |
| SCHEMBL10434485 | 0.82 | HRH1 (0.49) | HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |
| US-4943580-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |