Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 6/20 | 0.46 |
| ▸ | WNT3A | P56704 | 6/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597997 | 0.86 | CTNNB1 (0.46) | CTNNB1WNT3AAXLMERTKRAB9A | |
| SCHEMBL9327652 | 0.76 | CTNNB1 (0.55) | CTNNB1WNT3ARAB9AKEAP1NFE2L2 | |
| SCHEMBL28363090 | 0.75 | CTNNB1 (0.46) | CTNNB1WNT3AAXLMERTKRAB9A | |
| SCHEMBL28321960 | 0.75 | CTNNB1 (0.46) | CTNNB1WNT3AAXLMERTKRAB9A | |
| SCHEMBL5023473 | 0.75 | CTNNB1 (0.46) | CTNNB1WNT3AAXLMERTKRAB9A | |
| SCHEMBL10366473 | 0.75 | CTNNB1 (0.49) | CTNNB1WNT3AAXLMERTKRAB9A | |
| SCHEMBL5792636 | 0.74 | CTNNB1 (0.50) | CTNNB1WNT3ARAB9AKEAP1NFE2L2 | |
| SCHEMBL30730257 | 0.74 | CTNNB1 (0.47) | CTNNB1WNT3ARAB9AKCNH2NPC1 | |
| SCHEMBL16416836 | 0.72 | CTNNB1 (0.43) | CTNNB1WNT3AAXLMERTKRAB9A | |
| SCHEMBL1726294 | 0.72 | CTNNB1 (0.61) | CTNNB1WNT3ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256789-A | Antiinflammatory hydroxamic acids and N-hydroxyureas | PFIZER INC. (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0525111-A1 | ANTIINFLAMMATORY HYDROXAMIC ACIDS AND N-HYDROXYUREAS. | PFIZER (US) | 1993-02-03 | — | — | EP | disclosed |
| WO-1991016298-A1 | ANTIINFLAMMATORY HYDROXAMIC ACIDS AND N-HYDROXYUREAS | PFIZER INC (US) | 1991-10-31 | — | — | WO | disclosed |