Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537175 | 0.87 | HRH1 (0.53) | ALDH1A1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL5626341 | 0.86 | MEN1 (0.66) | ALDH1A1MEN1KMT2ACYP1A2CYP2D6 | |
| Bromide SCHEMBL9538473 | 0.82 | NPY1R (0.44) | KCNH2 | |
| SCHEMBL9539219 | 0.82 | HRH1 (0.42) | ALDH1A1MEN1KMT2AGRM2KCNH2 | |
| Hydrochloric Acid SCHEMBL10550355 | 0.81 | KCNH2 (0.50) | MEN1KMT2ACYP1A2CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL9538675 | 0.81 | KCNH2 (0.49) | MEN1KMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8138405 | 0.81 | MEN1 (0.51) | ALDH1A1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL9535902 | 0.80 | MEN1 (0.63) | ALDH1A1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL9536543 | 0.80 | SSTR5 (0.66) | ALDH1A1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL9539084 | 0.80 | MEN1 (0.52) | ALDH1A1MEN1KMT2ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |