Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 5/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538063 | 0.81 | KCNH2 (1.00) | KCNH2HTR1ASLC6A4DRD4NPC1 | |
| SCHEMBL9689872 | 0.78 | KCNH2 (0.90) | KCNH2HTR1ASLC6A4DRD4NPC1 | |
| SCHEMBL5338493 | 0.77 | CHRNA7 (0.70) | GRIN1GRIN2BHTR1ACHRNA7DRD4 | |
| SCHEMBL7097193 | 0.77 | GRIN2B (0.62) | GRIN1GRIN2BHTR1ACHRNA7DRD4 | |
| Hydrochloric Acid SCHEMBL9537707 | 0.76 | KCNH2 (0.58) | KCNH2HTR1ASLC6A4DRD4SMN1; SMN2 | |
| SCHEMBL7972912 | 0.76 | GRIN2B (0.83) | GRIN1GRIN2BCHRNA7DRD4 | |
| SCHEMBL7102398 | 0.76 | GRIN2B (0.74) | GRIN1GRIN2BHTR1ACHRNA7DRD4 | |
| Hydrochloric Acid SCHEMBL10798502 | 0.76 | KCNH2 (0.57) | KCNH2HTR1ASLC6A4DRD4SMN1; SMN2 | |
| SCHEMBL25334690 | 0.75 | NPC1 (0.64) | GRIN1GRIN2BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL32680055 | 0.75 | NPC1 (0.64) | GRIN1GRIN2BNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |