Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6021886 | 0.78 | TDP1 (0.42) | TDP1ALDH1A1SMN1; SMN2TSHRTP53 | |
| SCHEMBL28675474 | 0.75 | TDP1 (0.40) | TDP1ALDH1A1SMN1; SMN2TSHRTP53 | |
| SCHEMBL20388803 | 0.75 | TDP1 (0.40) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9589101 | 0.75 | MEN1 (0.37) | TDP1ALDH1A1 | |
| SCHEMBL671115 | 0.75 | TDP1 (0.38) | TDP1TSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL9132176 | 0.73 | CYP3A4 (0.44) | CYP2C19ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL3402458 | 0.73 | TDP1 (0.35) | TDP1ALDH1A1 | |
| SCHEMBL9132179 | 0.72 | CYP3A4 (0.40) | TDP1CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL27259892 | 0.71 | CYP2C19 (0.43) | CYP2C19ALDH1A1KDM4EMAPTALOX15 | |
| SCHEMBL1778182 | 0.71 | CYP2C19 (0.41) | CYP2C19ALDH1A1KDM4EMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254595-A | Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them | ELF SANOFI (FR) | 1993-10-19 | — | — | US | disclosed |
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0375560-A1 | Aryloxypropanolaminotetralines, process for their preparation and pharmaceutical compositions containing same | ELF SANOFI (FR) | 1990-06-27 | — | — | EP | disclosed |