Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.61 |
| ▸ | BCHE | P06276 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537191 | 0.90 | BCHE (0.66) | BCHEACHEKDM4EHIF1AHSD17B10 | |
| SCHEMBL8827805 | 0.90 | BCHE (0.66) | BCHEACHEKDM4EHIF1AHSD17B10 | |
| SCHEMBL8827803 | 0.90 | BCHE (0.66) | BCHEACHEKDM4EHIF1AHSD17B10 | |
| Salicylic Acid SCHEMBL9541012 | 0.87 | KDM4E (0.55) | BCHEACHEKDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL9539721 | 0.86 | BCHE (0.57) | BCHEACHEKDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL8827810 | 0.85 | KDM4E (0.72) | BCHEACHEKDM4EALDH1A1HPGD | |
| SCHEMBL9538390 | 0.85 | BCHE (0.73) | BCHEACHE | |
| Salicylic Acid SCHEMBL9538265 | 0.85 | BCHE (0.48) | BCHEACHE | |
| SCHEMBL9013963 | 0.79 | BCHE (0.64) | BCHEACHE | |
| SCHEMBL8863731 | 0.76 | BCHE (0.72) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187165-A | Eseroline derivatives; cholinergic agents; antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-02-16 | — | — | US | disclosed |