Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.58 |
| ▸ | FEN1 | P39748 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29364863 | 1.00 | TDP1 (0.62) | TDP1ERCC5FEN1ALDH1A1MAPK1 | |
| SCHEMBL5775638 | 0.88 | ERCC5 (0.58) | TDP1ERCC5FEN1ALDH1A1KMT2A | |
| SCHEMBL4372575 | 0.85 | ERCC5 (0.63) | TDP1ERCC5FEN1ALDH1A1MAPK1 | |
| Imidazole SCHEMBL1867973 | 0.85 | TDP1 (0.49) | TDP1ERCC5FEN1ALDH1A1MAPK1 | |
| SCHEMBL7131562 | 0.85 | TDP1 (0.47) | TDP1ERCC5FEN1ALDH1A1MAPK1 | |
| SCHEMBL30228141 | 0.85 | TDP1 (0.47) | TDP1ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL7127425 | 0.85 | TDP1 (0.47) | TDP1ERCC5FEN1ALDH1A1MAPK1 | |
| SCHEMBL3412192 | 0.85 | TDP1 (0.47) | TDP1ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL1110081 | 0.85 | ERCC5 (0.63) | TDP1ERCC5FEN1ALDH1A1MAPK1 | |
| SCHEMBL30683710 | 0.85 | ERCC5 (0.63) | TDP1ERCC5FEN1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7316099-A | — | — | None | — | — | JP | disclosed |
| CN-113980001-B | Pyrazolol-pyridazinone coupling compound, pharmaceutical composition thereof and application of pyrazolol-pyridazinone coupling compound in medicines | 贵州医科大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-108558833-B | Pyrazole alcohol compound, pharmaceutical composition thereof and application thereof in medicines | 贵州医科大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-113980001-A | Pyrazole alcohol-pyridazinone coupling compound, pharmaceutical composition thereof and application thereof in medicines | 贵州医科大学 | 2022-01-28 | — | — | CN | disclosed |
| EP-2496570-B1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-06-29 | — | — | EP | disclosed |
| EP-1931677-B1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-04-20 | — | — | EP | disclosed |
| EP-2769980-B1 | PYRAZOLOQUINOLINE DERIVATIVE AS PDE9 INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2016-02-03 | — | — | EP | disclosed |
| US-9139589-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9139589-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9139589-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |
| CN-1142492-A | Substituted N-(indole-2-carbonyl)-glycinamides and derivatives as antidiabetic agents | PFIZER (US) | 1997-02-12 | — | — | CN | disclosed |
| JP-H07316099-A | PRODUCTION OF SUBSTITUTED BENZOYL FATTY ACID DERIVATIVE | NIPPON NOHYAKU CO LTD | 1995-12-05 | — | — | JP | disclosed |
| WO-1995019967-A1 | A PROCESS FOR THE PREPARATION OF 3-(SUBSTITUTED PHENYL) PYRAZOLE DERIVATIVES | ZENECA LIMITED (GB) | 1995-07-27 | — | — | WO | disclosed |
| US-4959363-A | HERPES VIRUS | STERLING DRUG INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0027018-B1 | PROCESS FOR THE PRODUCTION OF 2-CHLORO-4-SUBSTITUTED-5-THIAZOLECARBOXYLATES | MONSANTO COMPANY (US) | 1983-10-05 | — | — | EP | disclosed |
| US-4336389-A | 2-Substituted-4-aryl-5-thiazolecarboxylic acids and their derivatives as safening agents | MONSANTO COMPANY (US) | 1982-06-22 | — | — | US | disclosed |
| US-4308391-A | 2-Amino-4-substituted-thiazolecarboxylic acids and their derivatives | MONSANTO COMPANY (US) | 1981-12-29 | — | — | US | disclosed |
| EP-0027018-A1 | Process for the production of 2-chloro-4-substituted-5-thiazolecarboxylates | MONSANTO COMPANY (US) | 1981-04-15 | — | — | EP | disclosed |