Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566625 | 0.80 | TSHR (0.44) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL16109306 | 0.79 | GAA (0.60) | BRD4MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL11665099 | 0.79 | MEN1 (0.60) | BRD4MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL11762704 | 0.77 | ATM (0.70) | MEN1KMT2AHTTMAPT | |
| SCHEMBL11747743 | 0.76 | MEN1 (0.54) | MEN1KMT2AHTTUSP7MAPT | |
| SCHEMBL11761878 | 0.76 | MEN1 (0.54) | MEN1KMT2AHTTUSP7MAPT | |
| SCHEMBL11154462 | 0.75 | MEN1 (0.65) | MEN1KMT2AHTTMAPT | |
| SCHEMBL11152349 | 0.75 | MEN1 (0.64) | MEN1KMT2AHTTMAPT | |
| SCHEMBL16109596 | 0.74 | BRD4 (0.52) | BRD4MEN1KMT2AGAA | |
| SCHEMBL11765367 | 0.74 | MEN1 (0.63) | MEN1KMT2AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530994-A1 | Quinazoline derivatives as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1993004047-A1 | QUINAZOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-04 | — | — | WO | disclosed |