Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.51 |
| ▸ | HRH1 | P35367 | 3/20 | 0.51 |
| ▸ | TACR2 | P21452 | 2/20 | 0.51 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
| ▸ | EED | O75530 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HLA-A | P04439 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10551708 | 0.93 | HRH1 (0.49) | KCNH2HRH1TACR2TACR1EED | |
| Hydrochloric Acid SCHEMBL10550355 | 0.84 | KCNH2 (0.50) | KCNH2HRH1TACR2TACR1EED | |
| SCHEMBL1152441 | 0.84 | KCNH2 (0.72) | KCNH2HRH1TACR2TACR1EED | |
| Hydrochloric Acid SCHEMBL9537707 | 0.84 | KCNH2 (0.58) | KCNH2HRH1TACR2TACR1EED | |
| Hydrochloric Acid SCHEMBL9538675 | 0.84 | KCNH2 (0.49) | KCNH2HRH1TACR2TACR1EED | |
| SCHEMBL9540175 | 0.84 | KCNH2 (0.71) | KCNH2HRH1TACR2TACR1EED | |
| Hydrochloric Acid SCHEMBL10798502 | 0.83 | KCNH2 (0.57) | KCNH2HRH1TACR2TACR1EED | |
| SCHEMBL9539005 | 0.82 | TP53 (0.64) | KCNH2HRH1TACR2TACR1EED | |
| SCHEMBL9536010 | 0.82 | HRH1 (0.55) | KCNH2HRH1TACR2TACR1EED | |
| Hydrochloric Acid SCHEMBL9540285 | 0.80 | KCNH2 (0.55) | KCNH2HRH1TACR2TACR1EED |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |