Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540165 | 0.95 | KDM4E (0.47) | KDM4ELMNAHTTL3MBTL1FABP4 | |
| SCHEMBL9540062 | 0.76 | KDM4E (0.51) | KDM4ELMNAHTTL3MBTL1FABP4 | |
| SCHEMBL11635515 | 0.76 | MAPT (0.47) | KDM4ELMNAHTTGAAALOX15 | |
| SCHEMBL9540153 | 0.73 | KDM4E (0.50) | KDM4ELMNAHTTL3MBTL1FABP4 | |
| SCHEMBL9539113 | 0.73 | KDM4E (0.48) | KDM4ELMNAHTTL3MBTL1FABP4 | |
| SCHEMBL9542746 | 0.69 | HRH3 (0.42) | MAT2AKCNH2HRH3NPC1RAB9A | |
| SCHEMBL25373437 | 0.68 | MAPK8 (0.51) | FABP4FABP5 | |
| SCHEMBL9539742 | 0.66 | AURKA (0.52) | KDM4ELMNAHTTL3MBTL1EGFR | |
| SCHEMBL25373040 | 0.65 | MAPK8 (0.51) | FABP4FABP5 | |
| SCHEMBL9539747 | 0.65 | KDM4E (0.47) | KDM4ELMNAHTTL3MBTL1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530994-A1 | Quinazoline derivatives as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1993004047-A1 | QUINAZOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-04 | — | — | WO | disclosed |