Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.63 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542305 | 1.00 | PDGFRB (0.63) | PDGFRBSIRT2KDRTGM2MDM2 | |
| SCHEMBL250564 | 0.86 | LRRK2 (0.56) | MDM2 | |
| SCHEMBL250565 | 0.86 | LRRK2 (0.56) | MDM2 | |
| SCHEMBL14674887 | 0.86 | PDGFRB (0.77) | PDGFRBSIRT2KDRTGM2MDM2 | |
| SCHEMBL14675150 | 0.86 | PDGFRB (0.77) | PDGFRBSIRT2KDRTGM2MDM2 | |
| SCHEMBL4723150 | 0.84 | PDGFRB (0.60) | PDGFRBKDRTGM2MDM2 | |
| SCHEMBL13929117 | 0.84 | PDGFRB (0.60) | PDGFRBKDRTGM2MDM2 | |
| SCHEMBL14675079 | 0.82 | PDGFRB (0.64) | PDGFRBKDRTGM2MDM2PARP1 | |
| SCHEMBL14675080 | 0.82 | PDGFRB (0.64) | PDGFRBKDRTGM2MDM2PARP1 | |
| SCHEMBL14448902 | 0.82 | PDGFRB (0.62) | PDGFRBKDRIGF1RPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993012786-A1 | INDOLINONE DERIVATIVES | HOWARD HARRY R JR (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5064852-A | Antidiabetic agents; aldose reductase inhibitors | PFIZER INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4960785-A | Indolinone derivatives | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0252713-B1 | INDOLINONE DERIVATIVES | PFIZER INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| EP-0252713-A1 | Indolinone derivatives | PFIZER INC. (US) | 1988-01-13 | — | — | EP | disclosed |