Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24742856 | 0.97 | — | — | |
| SCHEMBL593886 | 0.97 | — | — | |
| SCHEMBL10020235 | 0.70 | TSHR (0.44) | — | |
| SCHEMBL13954334 | 0.67 | — | — | |
| SCHEMBL14354358 | 0.67 | TSHR (0.52) | — | |
| SCHEMBL131371 | 0.67 | TSHR (0.39) | — | |
| SCHEMBL3453860 | 0.63 | — | — | |
| SCHEMBL4228851 | 0.63 | — | — | |
| SCHEMBL437096 | 0.63 | — | — | |
| SCHEMBL21767 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013092-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | SARGES REINHARD (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5011840-A | Imidazolidinedione derivatives in diabetes treatment | PFIZER INC. (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0269355-B1 | IMIDAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-04-10 | — | — | EP | disclosed |
| EP-0269355-A1 | Imidazolidinedione derivatives | PFIZER INC. (US) | 1988-06-01 | — | — | EP | disclosed |