Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.54 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 14/20 | 0.51 |
| ▸ | CTSD | P07339 | 4/20 | 0.51 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9544389 | 1.00 | DPP4 (0.54) | DPP4DPP8DPP9BACE1CTSD | |
| SCHEMBL29777789 | 1.00 | DPP4 (0.54) | DPP4DPP8DPP9BACE1CTSD | |
| SCHEMBL30463268 | 0.97 | DPP4 (0.56) | DPP4DPP8DPP9BACE1CTSD | |
| SCHEMBL29517333 | 0.97 | DPP4 (0.56) | DPP4DPP8DPP9BACE1CTSD | |
| SCHEMBL9293719 | 0.96 | BACE1 (0.51) | DPP4DPP8DPP9BACE1CTSD | |
| SCHEMBL9293727 | 0.96 | BACE1 (0.51) | DPP4DPP8DPP9BACE1CTSD | |
| SCHEMBL29777835 | 0.95 | BACE1 (0.53) | DPP4DPP8DPP9BACE1CTSD | |
| SCHEMBL30479086 | 0.95 | BACE1 (0.53) | DPP4DPP8DPP9BACE1CTSD | |
| SCHEMBL29777826 | 0.95 | BACE1 (0.53) | DPP4DPP8DPP9BACE1CTSD | |
| SCHEMBL30799949 | 0.93 | BACE1 (0.48) | DPP4DPP8DPP9BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993009233-A2 | RECOMBINANT AMYLOID PRECURSOR PROTEIN INHIBITOR DOMAIN AND TREATMENT OF VARIOUS DISEASE STATES | THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES INC. (US) | 1993-05-13 | — | — | WO | disclosed |
| WO-1991005057-A1 | CD4 PRODUCTION IN PICHIA PASTORIS | THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES, INC. (US) | 1991-04-18 | — | — | WO | disclosed |
| EP-0206783-A2 | Expression and secretion of polypeptides from saccharomyces cerevisiae | The Salk Institute Biotechnology Industrial Associates, Inc. (US) | 1986-12-30 | — | — | EP | disclosed |