SCHEMBL9544879

SCHEMBL9544879

CC(OCc1ccccc1)C(NC(=O)OC(C)(C)C)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ACE P12821 8/20 0.51
ABCB11 O95342 1/20 0.49
CMA1 P23946 1/20 0.45
AGTR2 P50052 1/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
CXCR3 P49682 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9544886 1.00 ACE (0.51) ACEABCB11CMA1AGTR2MEN1
SCHEMBL9544283 0.88 KMT2A (0.43) CMA1MEN1KMT2ACXCR3
SCHEMBL9544282 0.88 KMT2A (0.43) CMA1MEN1KMT2ACXCR3
SCHEMBL27726228 0.86 ACE (0.56) ACEABCB11CMA1HDAC8
SCHEMBL27726229 0.86 ACE (0.56) ACEABCB11CMA1HDAC8
SCHEMBL9545013 0.86 ACE (0.56) ACEABCB11CMA1HDAC8
SCHEMBL9545015 0.86 ACE (0.56) ACEABCB11CMA1HDAC8
SCHEMBL27726218 0.85 ACE (0.55) ACEABCB11CMA1HDAC8CXCR3
SCHEMBL27726215 0.85 ACE (0.55) ACEABCB11CMA1HDAC8CXCR3
SCHEMBL27705636 0.85 ACE (0.54) ACEABCB11KMT2AHDAC8CXCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993020099-A2 CCK AND/OR GASTRIN RECEPTOR LIGANDS FERRING B.V. (NL) 1993-10-14 WO disclosed