Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9546724 | 1.00 | BACE1 (0.49) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546731 | 1.00 | BACE1 (0.49) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546633 | 0.93 | PSEN1 (0.54) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546623 | 0.93 | PSEN1 (0.54) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546639 | 0.93 | PSEN1 (0.54) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546614 | 0.93 | PSEN1 (0.54) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546685 | 0.90 | KMT2A (0.43) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546677 | 0.90 | KMT2A (0.43) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546694 | 0.90 | KMT2A (0.43) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546679 | 0.90 | PSEN1 (0.49) | BACE1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993023373-A1 | N-[N'-(5-AMINO-4-HYDROXY-ACYLOYL)-α-AMINOACYLOYL] SUBSTITUTED HETEROCYCLES AND THEIR USE AS ANTIVIRAL AGENTS | PFIZER LIMITED (GB) | 1993-11-25 | — | — | WO | disclosed |