Sugi Predict

Sugi Predict / Compounds / SCHEMBL9548189

SCHEMBL9548189

SCHEMBL9548189

[CH2]CNC(=O)CNC(=O)[C@@H]1CCC(=O)N1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.44
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ POLB P06746 1/20 0.39
▸ TERT O14746 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ ITGB1 P05556 1/20 0.33
▸ ITGA5 P08648 1/20 0.33
▸ PARP1 P09874 2/20 0.32
▸ HDAC3 O15379 2/20 0.32
▸ HDAC1 Q13547 2/20 0.32
▸ HDAC2 Q92769 2/20 0.32
▸ HDAC10 Q969S8 2/20 0.32
▸ HDAC11 Q96DB2 2/20 0.32
▸ HDAC8 Q9BY41 2/20 0.32
▸ HDAC6 Q9UBN7 2/20 0.32
▸ NCOR2 Q9Y618 1/20 0.32
▸ HPGDS O60760 1/20 0.31
▸ TRHR P34981 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9548185 0.89 SMN1; SMN2 (0.49) SMN1; SMN2MEN1KMT2APOLBGAA
SCHEMBL9548186 0.88 SMN1; SMN2 (0.46) SMN1; SMN2MEN1KMT2APOLBTERT
SCHEMBL9548184 0.88 SMN1; SMN2 (0.46) SMN1; SMN2MEN1KMT2APOLBTERT
SCHEMBL9548182 0.82 SMN1; SMN2 (0.43) SMN1; SMN2MEN1KMT2APOLBTERT
SCHEMBL9548183 0.82 SMN1; SMN2 (0.43) SMN1; SMN2MEN1KMT2APOLBTERT
SCHEMBL158183 0.81 SMN1; SMN2 (0.48) SMN1; SMN2MEN1KMT2APOLBGAA
SCHEMBL158182 0.81 SMN1; SMN2 (0.48) SMN1; SMN2MEN1KMT2APOLBGAA
SCHEMBL19545544 0.80 SMN1; SMN2 (0.47) SMN1; SMN2MEN1KMT2APOLBGAA
SCHEMBL9548205 0.79 SMN1; SMN2 (0.51) SMN1; SMN2MEN1KMT2APOLBGAA
SCHEMBL9548201 0.79 SMN1; SMN2 (0.51) SMN1; SMN2MEN1KMT2APOLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5227496-A PYROGLUTAMIC ACID DERIVATIVES AS ENHANCERS OF LEARNING PROCESSES AND MEMORY AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 1993-07-13 — — US claimed
EP-0511943-A2 Pyroglutamic acid derivatives as enhancers of learning processes and memory and pharmaceutical compositions comprising same Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 1992-11-04 — — EP claimed
JP-5117232-A — — None — — JP disclosed
US-5227496-A PYROGLUTAMIC ACID DERIVATIVES AS ENHANCERS OF LEARNING PROCESSES AND MEMORY AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 1993-07-13 — — US disclosed
US-5227496-A PYROGLUTAMIC ACID DERIVATIVES AS ENHANCERS OF LEARNING PROCESSES AND MEMORY AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 1993-07-13 — — US disclosed
JP-H05117232-A PYROGLUTAMIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION SIGMA TAU IND FARMACEUT RIUNITE SPA 1993-05-14 — — JP disclosed
EP-0511943-A3 PYROGLUTAMIC ACID DERIVATIVES AS ENHANCERS OF LEARNING PROCESSES AND MEMORY AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 1992-12-09 — — EP disclosed
EP-0511943-A2 Pyroglutamic acid derivatives as enhancers of learning processes and memory and pharmaceutical compositions comprising same Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 1992-11-04 — — EP disclosed
EP-0511943-A2 Pyroglutamic acid derivatives as enhancers of learning processes and memory and pharmaceutical compositions comprising same Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 1992-11-04 — — EP disclosed