Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.38 |
| ▸ | RARB | P10826 | 5/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9553703 | 0.96 | TSHR (0.52) | TSHRHSD17B10MEN1KMT2AHIF1A | |
| SCHEMBL9553062 | 0.96 | TSHR (0.52) | TSHRHSD17B10MEN1KMT2AHIF1A | |
| SCHEMBL9552742 | 0.89 | TSHR (0.48) | TSHRHSD17B10MEN1KMT2ARARB | |
| SCHEMBL9553570 | 0.89 | TSHR (0.48) | TSHRHSD17B10MEN1KMT2ARARB | |
| SCHEMBL9552869 | 0.89 | KMT2A (0.56) | TSHRHSD17B10MEN1KMT2ANR1H2 | |
| SCHEMBL8939299 | 0.88 | HDAC2 (0.47) | TSHRHSD17B10HDAC2FDFT1 | |
| SCHEMBL9552934 | 0.87 | MEN1 (0.43) | TSHRHSD17B10MEN1KMT2AHIF1A | |
| SCHEMBL9553047 | 0.86 | TSHR (0.45) | TSHRHSD17B10MEN1KMT2AHIF1A | |
| SCHEMBL11744015 | 0.86 | HDAC2 (0.49) | TSHRHSD17B10HDAC2FDFT1 | |
| SCHEMBL9553611 | 0.84 | MEN1 (0.44) | TSHRHSD17B10MEN1KMT2ARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252252-A | Longitudinal polarization | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1993-10-12 | — | — | US | disclosed |
| US-5120467-A | Longitudinal polarization and-or cross-polarization | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-06-09 | — | — | US | disclosed |
| US-4723005-A | CONTAINING POLARIZED CYANO OR HALOGEN SUBSTITUENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0139996-A1 | Anisotropic compounds and liquid crystal mixtures | MERCK PATENT GmbH (DE) | 1985-05-08 | — | — | EP | disclosed |