Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | STS | P08842 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADK | P55263 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439802 | 0.90 | POLB (0.57) | MEN1KMT2ASMARCA2SMARCA4PBRM1 | |
| SCHEMBL20657938 | 0.85 | MEN1 (0.55) | MEN1KMT2ASMARCA2SMARCA4PBRM1 | |
| SCHEMBL4566835 | 0.85 | SMARCA2 (0.54) | MEN1KMT2ASMARCA2SMARCA4PBRM1 | |
| SCHEMBL7049612 | 0.85 | MEN1 (0.55) | NR1H4MEN1KMT2ASMARCA2SMARCA4 | |
| SCHEMBL12516958 | 0.85 | SMARCA2 (0.57) | MEN1KMT2ASMARCA2SMARCA4PBRM1 | |
| SCHEMBL161275 | 0.85 | MEN1 (0.59) | MEN1KMT2ASMARCA2SMARCA4PBRM1 | |
| SCHEMBL2365793 | 0.85 | MEN1 (0.58) | MEN1KMT2AMAPTALDH1A1STS | |
| SCHEMBL30208133 | 0.85 | MEN1 (0.58) | MEN1KMT2AMAPTALDH1A1STS | |
| SCHEMBL23435151 | 0.83 | MEN1 (0.60) | MEN1KMT2ASMARCA2SMARCA4PBRM1 | |
| SCHEMBL30335739 | 0.83 | MEN1 (0.60) | MEN1KMT2ASMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796274-B2 | Piperazine derivatives and their use in controlling pests | SYNGENTA CROP PROTECTION LLC (US) | 2014-08-05 | — | — | US | disclosed |
| CN-1976586-B | Piperazine derivatives and their use for controlling pests | SYNGENTA PARTICIPATIONS AG | 2014-06-25 | — | — | CN | disclosed |
| EP-1755396-B1 | PIPERAZIN DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| CN-103734137-A | Piperazin derivatives and their use in controlling pests | SYNGENTA PARTICIPATIONS AG | 2014-04-23 | — | — | CN | disclosed |
| US-20110003991-A1 | PIPERAZINE DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-7807679-B2 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | SYNGENTA CROP PROTECTION, INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20080076777-A1 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | SYNGENTA CROP PROTECTION, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| CN-1976586-A | Piperazine derivatives and their use for controlling pests | SYNGENTA PARTICIPATIONS AG (CH) | 2007-06-06 | — | — | CN | disclosed |
| EP-1755396-A1 | PIPERAZIN DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | Syngeta Participations AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115146-A1 | PIPERAZIN DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003991-A1 | PIPERAZINE DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | CHRM1, CHRM5, PRMT5 | NR1H4 3843/4885MEN1 3554/4885KMT2A 1508/4885 |
| US-20080076777-A1 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | CHRM1, CHRM2, CHRM5 | NR1H4 2587/4885MEN1 4330/4885KMT2A 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.