Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30682949 | 0.74 | BRD4 (0.36) | ALDH1A1 | |
| SCHEMBL102202 | 0.74 | MEN1 (0.33) | CYP3A4 | |
| SCHEMBL1188205 | 0.74 | CSNK2A2 (0.30) | — | |
| SCHEMBL27513844 | 0.72 | MEN1 (0.33) | CYP3A4 | |
| Hydrochloric Acid SCHEMBL29616692 | 0.72 | GDA (0.35) | CSNK1A1TYRO3DYRK1BKDM4ECYP3A4 | |
| Hydrochloric Acid SCHEMBL21683018 | 0.72 | GDA (0.35) | CSNK1A1TYRO3DYRK1BKDM4ECYP3A4 | |
| SCHEMBL17541171 | 0.71 | CSNK1A1 (0.45) | CSNK1A1TYRO3DYRK1BALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL28120813 | 0.70 | CSNK1A1 (0.44) | CSNK1A1TYRO3DYRK1BALDH1A1CYP3A4 | |
| SCHEMBL31627252 | 0.69 | CSNK1A1 (0.51) | CSNK1A1TYRO3DYRK1BKDM4EALDH1A1 | |
| SCHEMBL15109735 | 0.69 | LRRK2 (0.34) | CYP3A4CYP3A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112645956-A | Preparation method of prodrug intermediate of thymidine phosphorylase inhibitor | 天津全和诚科技有限责任公司 | 2021-04-13 | — | — | CN | claimed |
| CN-110790768-A | Production system of medical intermediate 4-chloro-pyrrolopyrimidine | 廖文杰 | 2020-02-14 | — | — | CN | claimed |
| EP-0576211-B1 | Process for the synthesis of 4-hydroxy-5-halopyrrolo 2,3-D pyrimidine intermediates | LILLY CO ELI (US) | 2001-08-22 | — | — | EP | claimed |
| EP-0595467-B1 | Process for preparing antifolate 4-hydroxypyrrolo 2,3-d pyrimidine derivatives | LILLY CO ELI (US) | 2000-07-19 | — | — | EP | claimed |
| US-5426187-A | Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | claimed |
| EP-0595467-A2 | Process for preparing antifolate 4-hydroxypyrrolo 2,3-d pyrimidine derivatives | ELI LILLY AND COMPANY (US) | 1994-05-04 | — | — | EP | claimed |
| US-5278307-A | Process for preparing 4-hydroxypyrrolo(2,3-d)pyrimidine based antifolate compounds and intermediates | ELI LILLY AND COMPANY (US) | 1994-01-11 | — | — | US | claimed |
| EP-0576211-A2 | Process for the synthesis of 4-hydroxy-5-halopyrrolo 2,3-D pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1993-12-29 | — | — | EP | claimed |
| JP-6056838-A | — | — | None | — | — | JP | disclosed |
| JP-6211863-A | — | — | None | — | — | JP | disclosed |
| CN-118317946-A | Processes and intermediates for the preparation of baratinib | 因赛特公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-117043152-A | Methods and intermediates for preparing JAK1 inhibitors | 因赛特公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-116761792-A | Methods and intermediates for preparing JAK inhibitors | 因赛特公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-4200278-A1 | PROCESS AND INTERMEDIATES FOR PREPARING A JAK1 INHIBITOR | Incyte Corporation (US) | 2023-06-28 | — | — | EP | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| US-5235053-A | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| US-5235053-A | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| EP-0549886-A1 | Process for the preparation of pyrrolo[2,3-d]pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |
| US-4996206-A | Antitumor agent | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-02-26 | — | — | US | disclosed |