Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 14/20 | 0.75 |
| ▸ | CYSLTR1 | Q9Y271 | 14/20 | 0.75 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475509 | 1.00 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1LPAR1TSHR | |
| SCHEMBL10459640 | 1.00 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1LPAR1TSHR | |
| SCHEMBL8925768 | 0.90 | CYSLTR2 (0.78) | CYSLTR2CYSLTR1 | |
| SCHEMBL9561170 | 0.88 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1LPAR1 | |
| SCHEMBL9561165 | 0.88 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1LPAR1 | |
| Pobilukast SCHEMBL6437479 | 0.86 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1 | |
| Pobilukast SCHEMBL125952 | 0.86 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1 | |
| Pobilukast SCHEMBL29473536 | 0.86 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1 | |
| Pobilukast SCHEMBL9508139 | 0.85 | CYSLTR2 (0.98) | CYSLTR2CYSLTR1 | |
| Pobilukast SCHEMBL9508133 | 0.85 | CYSLTR2 (0.98) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5189226-A | Chemical intermediate for diacid | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |
| US-4937253-A | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-26 | — | — | US | disclosed |
| EP-0365149-A2 | Leukotriene antagonist prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |