Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 8/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740346 | 0.93 | KCNA5 (0.40) | KCNA5ALDH1A1KMT2APOLBTSHR | |
| SCHEMBL12268284 | 0.89 | MAPT (0.39) | KCNA5ALDH1A1TSHRMAPT | |
| SCHEMBL9562796 | 0.88 | KCNA5 (0.37) | KCNA5TACR3ALDH1A1KMT2AMEN1 | |
| SCHEMBL8952823 | 0.87 | MAPT (0.38) | ABL1MAPT | |
| SCHEMBL8952810 | 0.87 | MAPT (0.38) | ABL1MAPT | |
| SCHEMBL25175870 | 0.87 | MAPT (0.38) | ABL1MAPT | |
| SCHEMBL29772371 | 0.87 | TSHR (0.41) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL23529640 | 0.87 | TSHR (0.41) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL3403997 | 0.86 | KCNA5 (0.42) | KCNA5ALDH1A1KMT2ATSHRMAPT | |
| SCHEMBL3779621 | 0.86 | KCNA5 (0.42) | KCNA5ALDH1A1KMT2ATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256692-A | Sulfur-containing HMG-COA reductase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5202327-A | PHOSPHORUS-CONTAINING HMG-COA REDUCTASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0522431-A1 | Phophorus-containing HMG-COA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1993-01-13 | — | — | EP | disclosed |