Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778997 | 1.00 | CYP1A2 (0.57) | CYP1A2MEN1KMT2ARAB9AATM | |
| SCHEMBL26343277 | 0.91 | CYP1A2 (0.58) | CYP1A2MEN1KMT2ARAB9AATM | |
| SCHEMBL2728932 | 0.90 | CYP1A2 (0.53) | CYP1A2MEN1KMT2ARAB9AATM | |
| SCHEMBL17009732 | 0.86 | CYP1A2 (0.53) | CYP1A2MEN1KMT2ARAB9AATM | |
| SCHEMBL4283725 | 0.86 | CYP1A2 (0.53) | CYP1A2MEN1KMT2ARAB9AATM | |
| SCHEMBL15577394 | 0.85 | CYP1A2 (0.53) | CYP1A2MEN1KMT2ARAB9AATM | |
| SCHEMBL15577420 | 0.85 | CYP1A2 (0.49) | CYP1A2MEN1KMT2ARAB9AATM | |
| SCHEMBL29706788 | 0.85 | CYP1A2 (0.53) | CYP1A2MEN1KMT2ARAB9AATM | |
| SCHEMBL17375033 | 0.85 | CYP1A2 (0.51) | CYP1A2MEN1KMT2AATMTDP1 | |
| SCHEMBL17009935 | 0.82 | CYP1A2 (0.49) | CYP1A2MEN1KMT2ARAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946282-B2 | Indolin-2-one derivatives as protein kinase inhibitors | Annji Pharmaceutical Co., Ltd. (TW) | 2015-02-03 | — | — | US | disclosed |
| US-5252536-A | Substituted indolinones useful as herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0549892-A1 | Substituted indolinones useful as herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |