Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15401745 | 0.78 | CHEK1 (0.53) | CHEK1DYRK1AHSP90AA1HSP90AB1MAPK1 | |
| SCHEMBL7886482 | 0.78 | DYRK1A (0.35) | DYRK1AHSP90AA1HSP90AB1MAPK1PIM1 | |
| SCHEMBL7887899 | 0.69 | CHEK1 (0.61) | CHEK1DYRK1AMAPK1PIM1DYRK1B | |
| SCHEMBL14158956 | 0.66 | CHEK1 (0.43) | CHEK1HSP90AA1HSP90AB1MAPK1 | |
| SCHEMBL7851196 | 0.66 | TYMS (0.48) | CHEK1MAPK1 | |
| SCHEMBL10307717 | 0.64 | DYRK1A (0.38) | DYRK1AHSP90AA1HSP90AB1PIM1DYRK2 | |
| SCHEMBL14197939 | 0.63 | — | — | |
| SCHEMBL11986721 | 0.63 | CHUK (0.41) | — | |
| SCHEMBL19710955 | 0.63 | DYRK1A (0.43) | DYRK1AHSP90AA1HSP90AB1PIM1DYRK2 | |
| SCHEMBL1017711 | 0.62 | CHEK1 (0.56) | CHEK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576211-A2 | Process for the synthesis of 4-hydroxy-5-halopyrrolo 2,3-D pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5235053-A | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1993-08-10 | — | — | US | disclosed |