Cephradine

Cephradine

SCHEMBL956675

CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)C3=CCC=CC3)[C@H]2SC1.O

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Cephradine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.98
HSD17B10 Q99714 7/20 0.98
KDM4E B2RXH2 6/20 0.98
KMT2A Q03164 6/20 0.98
CYP3A4 P08684 4/20 0.98
MEN1 O00255 4/20 0.98
CYP2C19 P33261 2/20 0.98
BLM P54132 2/20 0.98
NR1I2 O75469 2/20 0.98
ADORA3 P0DMS8 2/20 0.98
CYP2D6 P10635 1/20 0.98
PGR P06401 1/20 0.98
PTGS2 P35354 1/20 0.98
SLC15A1 P46059 1/20 0.98
PTGS1 P23219 1/20 0.77
ALDH1A1 P00352 6/20 0.67
SLC15A2 Q16348 3/20 0.67
HPGD P15428 3/20 0.67
TDP1 Q9NUW8 3/20 0.67
MAPK1 P28482 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cephradine SCHEMBL28758599 1.00 MAPT (0.98) MAPTHSD17B10KDM4EKMT2ACYP3A4
Cephradine SCHEMBL27547040 1.00 MAPT (0.98) MAPTHSD17B10KDM4EKMT2ACYP3A4
Cephradine SCHEMBL719332 1.00 MAPT (0.98) MAPTHSD17B10KDM4EKMT2ACYP3A4
Cephradine SCHEMBL16072830 0.99 MAPT (1.00) MAPTHSD17B10KDM4EKMT2ACYP3A4
Cephradine SCHEMBL20969062 0.99 MAPT (1.00) MAPTHSD17B10KDM4EKMT2ACYP3A4
Cephradine SCHEMBL11236414 0.99 MAPT (1.00) MAPTHSD17B10KDM4EKMT2ACYP3A4
Cephradine SCHEMBL11236409 0.99 MAPT (1.00) MAPTHSD17B10KDM4EKMT2ACYP3A4
Cephradine SCHEMBL13779346 0.99 MAPT (1.00) MAPTHSD17B10KDM4EKMT2ACYP3A4
Cephradine SCHEMBL3244 0.99 MAPT (1.00) MAPTHSD17B10KDM4EKMT2ACYP3A4
Cephradine SCHEMBL11209915 0.98 MAPT (0.98) MAPTHSD17B10KDM4EKMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117618440-A Application of cefradine monohydrate in preparation of cisplatin-resistant ototoxic drugs 山东第一医科大学(山东省医学科学院) 2024-03-01 CN claimed
EP-1641933-B1 PROCESS FOR THE PREPARATION OF CEPHRADINE DSM SINOCHEM PHARM NL BV (NL) 2017-12-20 EP claimed
EP-2513327-A2 PRODUCTION PROCESS FOR CEPHRADINE DSM Sinochem Pharmaceuticals Netherlands B.V. (NL) 2012-10-24 EP claimed
CN-102656274-A Process for producing cephradine DSM IP ASSETS BV 2012-09-05 CN claimed
WO-2011073166-A2 PRODUCTION PROCESS FOR CEPHRADINE DSM IP ASSETS B.V. (NL) 2011-06-23 WO claimed
US-7588913-B2 Process for the preparation of cephradine DSM IP ASSETS B.V. (NL) 2009-09-15 US claimed
CN-100507000-C Process for the preparation of cefradine DSM IP ASSETS BV (NL) 2009-07-01 CN claimed
US-20060189802-A1 Process for the preparation of cephradine DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) 2006-08-24 US claimed
CN-1813069-A Process for the preparation of cephradine DSM IP ASSETS BV (NL) 2006-08-02 CN claimed
EP-1641933-A2 PROCESS FOR THE PREPARATION OF CEPHRADINE DSM IP Assets B.V. (NL) 2006-04-05 EP claimed
WO-2005003367-A2 PROCESS FOR THE PREPARATION OF CEPHRADINE DSM IP ASSETS B.V. (NL) 2005-01-13 WO claimed
EP-0433428-B1 A STABLE FORM OF CEPHRADINE, PROCESS FOR ITS PRODUCTION AND INTERMEDIATES USED THEREIN BIOCHEMIE SA (ES) 1994-10-12 EP claimed
US-5278157-A Stable cephradine hydrate GEMA, S.A. (ES) 1994-01-11 US claimed
JP-8009630-B2 1992-02-13 JP claimed
US-5034522-A Silating, acylation, basification and solvent extraction BIOCRAFT LABORATORIES, INC. (US) 1991-07-23 US claimed
EP-0433428-A1 A STABLE FORM OF CEPHRADINE, PROCESS FOR ITS PRODUCTION AND INTERMEDIATES USED THEREIN. GEMA SA (ES) 1991-06-26 EP claimed
WO-1991000865-A1 A NOVEL STABLE FORM OF CEPHRADINE, PROCESS FOR ITS PRODUCTION AND INTERMEDIATES USED THEREIN GEMA S.A. (ES) 1991-01-24 WO claimed
CN-119700983-A Application of UBR5 in preparation of medicines for treating pigment dermatosis 中南大学湘雅医院 2025-03-28 CN disclosed
WO-1991000865-A1 A NOVEL STABLE FORM OF CEPHRADINE, PROCESS FOR ITS PRODUCTION AND INTERMEDIATES USED THEREIN GEMA S.A. (ES) 1991-01-24 WO disclosed
US-4139702-A Process for preparing cephalosporines DOBFAR S.P.A. (IT) 1979-02-13 US disclosed